Program

12:00 - 19:00

Registration

12:00 - 19:00

13:30 - 14:00 Plenary room

Opening cerimony

14:00 - 16:00

Parallel Symposia Sessions

14:00 - 16:00

Room A

Plasticity of neuronal circuits underlying the high, the crash and the perseverance in drug addiction

Chairman: Manuel Mameli, Switzerland

Philippe Faure, France
Nicotine effect on decision making and social behaviour
Vincent Pascoli, Switzerland
Neural plasticity underlying compulsive reinforcement
Yan Dong, USA 
Engram synapses in cocaine memories
Manuel Mameli, Switzerland 
Circuit mechanisms underlying the negative symtpoms of drug withdrawal
Carlos Paladini, USA
Acute morphine effects on midbrain dopamine neuron subthreshold activity in vivo

Room B

Application of rTMS in Addiction Medicine

Chairman: Ti-Fei YuanChina
Co-chair: Liana Fattore, Italy

Colleen Hanlon, USA
mPFC as the TMS target for cue-reactivity
Min Zhao, China
Treatment of methamphetamine addiction with rTMS
Yihong Yang, USA
Neuroimaging findings and brain stimulation
Vaughn R. Steele, USA
Accelerated TBS sessions for addiction treatment
TBC

Room B

16:00 - 16:30

Coffee break

16:30 - 18:30

Parallel Symposia Sessions

16:30 - 18:30

Room A

Improving performance in sports and exercise: the use and abuse of addictive drugs as a new health hazard

Chairman: Thomas Zandonai, Spain
Co-chair: Ana Peiró, Spain

Thomas Zandonai, Spain
Sport and physical exercise: foes or friends in the addiction field?
Ana Peiró, Spain
No pain no gain: gender difference in managing physical exercise pain through opioid and analgesics abuse
Lorenzo Zamboni, Italy
Benzodiazepine abuse among athletes: pain relief or just a weapon against insomnia? A new addiction phenomenon in sports
Astrid Bjørnebekk, Norway
Hooked on hormones – mechanisms and behavior associated with anabolic-androgenic steroid (AAS) dependence

Room B

Shedding light on the interaction between drugs of abuse and social behavior

Chairman: Viviana Trezza, Italy
Co-chair: Heidi Lesscher, The Netherlands

Klaus Miczek, USA
Neuroadaptations to social stress and persistent motivation to self-administer cocaine and alcohol in male and female rodents
Christelle Baunez, USA
Subthalamic nucleus involvement in the influence of proximal social factors on cocaine use
Irene Perini, Sweden
Neural substrates of social acceptance and rejection
Marco Venniro, USA
Volitional social interaction prevents drug addiction in rat models
Heidi Lesscher, The Netherlands
Social play and the sensitivity to rewards and addictive behaviour

Room B

19:00

Welcome cocktail

9:00 - 10:00 PLENARY LECTURE

Dangerous Liaisons: How a general theory of addiction subdues the development of new treatments

Pier Vincenzo Piazza

CEO Aelis Farma, Bordeaux
 
Foto Pier Vincenzo Piazza PNG

9:00 - 10:00 PLENARY LECTURE

10:00 - 10:30

Coffee break

10:30 - 12:30

Parallel Symposia Sessions

10:30 - 12:30

Room A

Cannabinoid actions in the brain: new fields, new players, new games

Chairman: Giovanni Marsicano, France

Marta Navarrete, Spain
Deciphering the role of the tripartite synapse in addictive behavior
Jean-Michel Revest, France
Role of Pregnenolone-like AEF0117 compound in the regulation of THC-induced hyperlocomotion
Giorgio Carmignoto, Italy
Astrocytes control excitation of Ventral Temental Area dopaminergic neurons
Giovanni Marsicano, France
New Mechanisms of cannabinoid signaling in the brain

Room B

Investigating the role of steroid hormones in vulnerability to addiction

Chairman: Patrizia Porcu, Italy
Co-chair: Kathleen Grant, USA

Kathleen A. Grant,USA
Steroid hormones and the risk for heavy alcohol drinking in non human primates
Rajita Sinha, USA
Steroid hormones, neurosteroids, craving and addiction relapse risk in humans
Monique Vallee, France
Pregnenolone and cannabis addiction: a new endogenous regulatory mechanism and therapeutic potential
Erin S. Calipari, USA
Cues play a critical role in estrous cycle-dependent cocaine reinforcement
Patrizia Porcu, Italy
Hormonal contraceptives and reward-related behavior in female rats

Room B

12:30 - 13:30

Lunch

14:00 - 16:00

Parallel Symposia Sessions

14:00 - 16:00

Room A

Non-pharmacological interventions to reduce drug taking and seeking: Implications for the treatment of Addictions

Chairman: Marcello Solinas, France
Co-chair: Marco Venniro, USA

Wendy Lynch, USA
Exercise as an anti-relapse intervention for cocaine: sex differences.
Marcello Solinas, France
Environmental enrichment and relapse to drug addiction: behavioral and neurobiological mechanisms
Thomas Green, USA
Preventive effects of environmental enrichment and identification of new molecular targets
Claudio D'Addario, Italy
Genetic and epigenetic of prodynorphin gene: preclinical and clinical evidence
Margaret Haney, USA
Human Laboratory Models of Drug Self-administration: Drug vs Money

Room B

Synthetic cannabinoids and synthetic cathinones- preclinical and clinical studies

Chairman: Aviv Weinstein, Israel
Co-chair: Matteo Marti, Italy

Laura Orsolini, UK-Italy
An insight into the NPS-induced ‘synthetic’/chemical psychoses: a new psychopathological entity?
Aviv Weinstein, Israel
Cognitive, personality and brain imaging studies in regular users of synthetic cannabinoids and psychiatric comorbidity.
Maria Antonietta De Luca, Italy
Neurobiological sequelae of contingent and not-contingent administration of the synthetic cannabinoid receptor agonist JWH-018
Jolanta B Zawilska, Poland
New biological activities of synthetic cathinones
Marta Torrens, Spain
Treatment of drug users with dual diagnosis

Room B

16:00 - 16:30

Coffee break

16:30 - 18:30

Parallel Symposia Sessions

16:30 - 18:30

Room A

Molecular mechanisms of synaptic plasticity underlying reward processing

Chairman: Rami Yaka, Israel

Rami Yaka, Israel
ZIP: A novel eraser peptide of cocaine-conditioned reward
Raffaella Tonini, Italy
Neuromodulated plasticity at glutamatergic reward inputs to the Locus Coeruleus
Yonathan Kupchik, Israel
Synaptic changes in the reward system in diet-induced obesity
Ana João Rodrigues, Portugal
LDT modulation of reward behaviors
Mercè Correa, Spain
Psicostimulants potentiate effort-mediated alcohol and sucrose seeking: the role of individual differences

Room B

Exploration into Future Targets for Addictions Pharmacotherapy

Chairman: Noelle Anastasio, USA
Co-chair: Umberto Spampinato, France

Noelle Anastasio, USA
Interrogations into the cortical N-methyl-D-receptor system in relapse vulnerability
Silvana Gaetani, Italy
Effects of acylethanolamides on “food addiction”: from the modulation of compulsive eating to the mitigation of withdrawal symptoms
John Neumaier, USA
Impact of opioid tolerance and withdrawal on gene expression in striatal microglia
Nazzareno Cannella, Italy
Nociceptin/Orphanin FQ Receptor antagonism attenuates alcohol drinking and seeking by action in the central amygdala and ventral tegmental area
Umberto Spampinato, France
The central serotonin2B receptor: control of mesocorticolimbic dopamine system and therapeutic implications for cocaine addiction

Room B

18:30 - 20:00

Poster session #1

9:00 - 10:00 PLENARY LECTURE

Translational research in addiction: Psychopharmacological studies in humans

Harriet de Wit 

Department of Psychiatry and Behavioral Neuroscience, University of Chicago
 
Foto Harriet de Wit PNG

9:00 - 10:00 PLENARY LECTURE

10:00 - 10:30

Coffee break

10:30 - 12:30

Parallel Symposia Sessions

10:30 - 12:30

Room A

Metaplasticity and Addiction: from mechanisms to behaviour

Chairman: Cristiano Chiamulera, Italy
Co-chair: Peter Kalivas, USA

Peter Kalivas, USA
Metaplasticity in the nucleus accumbens and ventral pallidum underlying cued cocaine and heroin seeking
Elisabetta Gerace,Italy
Toxic Metaplasticity: ethanol as a metaplastic agent enhancing withdrawal damage
Pauline Belujon, France
Incubation of maladaptive metaplasticity in the amygdala-insula pathway after chronic cocaine intake
Cristiano Chiamulera, Italy
Metaplastic modulation of sucrose-seeking renewal and instrumental memory reconsolidation
Davide Dulcis, USA
Early nicotine exposure induces metaplastic dopamine specification affecting drug preference

Room B

The multifaceted role of serotonin in substance use disorders

Chairman: Judith Homberg, The Netherlands
Co-chair: Fabio Fumagalli, Italy

Linda Simmler, Switzerland
Drug-adaptive behavior and cocaine-induced gene regulation in serotonin transporter mutant mice
Judith Homberg, The Netherlands
The role of the median and dorsal raphe nuclei in the transition from regular to compulsive cocaine intake
Lucia Caffino, Italy
From regular to compulsive cocaine intake in serotonin transporter knockout rats: the glutamatergic synapse
Kathryn Cunningham, USA
The role of the 5-HT2C receptor in reduced self-control during drug seeking behaviour
Magdalena Zaniewska, Poland
The role of the 5-HT2c receptor in nicotine withdrawal symptoms

Room B

12:30 - 13:30

Lunch

14:00 - 16:00

Parallel Symposia Sessions

14:00 - 16:00

Room A

Harms and risk factors associated with cannabis abuse

Chairman: Maria-Paz Viveros, Spain
Co-chair: Fernando Rodriguez de Fonseca, Spain

Diego Quattrone, United Kingdom
The impact of cannabis use and polygenic risk scores on psychopathology at first-episode psychosis
Gabriella Gobbi, Canada
Preclinical and clinical data elucidating the impact of long-term cannabis consumption in mood disorder
Valentina Lorenzetti, Australia
Neural alterations pre and post cannabis use onset: emerging findings from global neuroimaging consortia
Fernando Rodriguez de Fonseca, Spain
From the Kief’s Pipe to the subnanomolar-affinity Cannabinoid CB1 receptor agonists: the molecular basis of cannabis addiction from a historical perspective
Maria Scherma, Italy
Adolescent cannabinoid exposure and problematic patterns of drug use in adulthood

Room B

The impact of social and environmental experiences on brain and behavioral response to psychostimulants

Chairman: Valeria Carola, Italy
Co-chair: Rodrigo Grassi de Oliveira, Brazil

Rodrigo Grassi de Oliveira, Brazil
Early life stress, accelerated aging and cocaine addiction: extreme phenotypes and methylation profiling microarray study
Luisa
Lo Iacono, Italy
Early-life stress-induced immune activation and dopaminergic system development: the impact on cocaine addiction
Rossella Ventura, Italy
Early stress and cocaine vulnerability: the role of genotype
Jeremy Lambert, United Kingdom
Early Life Adversity impairs alpha2-GABAA receptor expression in the mouse nucleus accumbens & the behavioural effects of cocaine
Daniele Caprioli, Italy
The cellular mechanisms of the anti-craving effects of social interaction

Room B

16:00 - 16:30

Coffee break

16:30 - 18:30

Parallel Symposia Sessions

16:30 - 18:30

Room A

Transcranial Magnetic Stimulation in the Study and Treatment of Addiction

Chairman: Abraham Zangen, Israel
Co-chair: Marco Diana, Italy

Abraham Zangen, Israel
Deep TMS targeting the anterior cingulate cortex for the treatment of alcohol addiction: a clinical and imaging study
Bernard Le Foll, Canada
Modulating insula function for addiction treatment
Angela Sanna, Italy
iTBS of the bliateral PfCX in cocaine dependence
Elliot A.Stein, USA
Accelerated TBS in cocaine dependence
Giovanni Martinotti, Italy
Targeting cocaine addiction with rTMS
TBC

Room B

Perinatal to adolescent sensitive periods of vulnerability to cannabis

Chairman: Olivier Manzoni, France
Co-chair: Miriam Melis, Italy

Tiziana Rubino, Italy
Cannabis and adolescence: a dangerous relationship for brain maturation
Yasmin Hurd, USA
Translating cannabis and the developing brain
Steven Laviolette, Canada
Prenatal and adolescent cannabinoid exposure alters mesocorticolimbic biomarkers for emotional regulation and reward processing
Matthew Hill, Canada
The neurodevelopmental impacts of maternal cannabis vapour exposure
Olivier Manzoni, France
Perinatal deprogramming by cannabinoids

Room B

18:30 - 20:00

Poster session #2

20:30

Social dinner

20:30

9:00 - 10:00 PLENARY LECTURE

Neurobiology of Addiction: The Gain in the Brain is in the Pain

George Koob

Director, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
 
Foto Koob PNG

9:00 - 10:00 PLENARY LECTURE

10:00 - 10:30

Coffee break

10:30 - 12:30

Parallel Symposia Sessions

10:30 - 12:30

Room A

New Psychoactive Substances: focus on Novel Synthetic Opioids

Chairman: Gaetano Di Chiara, Italy
Co-chair: Maria Antonietta De Luca, Italy

Gaetano Di Chiara, Italy
Novel Synthetic Opioids: a social and medical  threat
Matteo Marti, Italy
Pharmaco-toxicological effects of novel synthetic opioids: in vitro and in vivo studies
Michael Baumann, USA
Preclinical pharmacology of fentanyl and non-fentanyl analogs in the street drug marketplace
Maria Paola Castelli, Italy
News from the JUSTSO project: overview of Novel Synthetic Opioids
Martin Eysberg The Netherlands
High time resolution analyses in online microdialysis experiments for Dopamine and Serotonin

Room B

Overlapping circuits in aversive, appetitive and addictive behaviors

Chairman: François Georges, France

Gary Aston-Jones, USA
Unraveling brain circuits for drug demand: a central role for orexin in addiction
Åsa Mackenzie, Sweden
Neurocircuitry analysis of the subthalamic nucleus in aversive behavior
Sebastian Fernandez, France
Circuit mechanisms involved in salience processing by laterodorsal tegmental neurons
François Georges, France
Cocaine use the circuit of novelty to trigger plasticity in dopamine neurons

Room B

12:30 - 13:30

Lunch

14:00 - 16:00

Parallel Symposia Sessions

14:00 - 16:00

Room A

Brain stimulation: from bench to bedside

Chairman: Antonello Bonci, USA
Co-chair: Graziella Madeo, Italy 

Guido Mannaioni, Italy
Role of rTMS in managing benzodiazepine abuse
Ti-Fei Yuan, China
Use  of rTMS in the treatment of stimulant use disorders
Graziella Madeo, Italy
Long-term effect of rTMS in a large cohort of patients with cocaine use disorders 
Jennifer Rodger, Australia
Brain stimulation for addiction: insights and challenges in preclinical models

Room B

Cannabinoid Dysregulation of Brain Circuits Involved in Reward and Psychiatric Disorders

Chairman: Carl Lupica, USA

Marta Di Forti, United Kingdom
High-potency cannabis use and the incidence of psychotic disorders
Stephanie Borgland, Canada
Obesogenic diet induced plasticityin the orbitofrontal cortex
Carla Cannizzaro, Italy
In-Utero THC and alcohol vulnerability: a role for NPY
Joseph Cheer, USA
Cannabinoid exposure in adolescence dysregulates genes that orchestrate dopamine development and cocaine-motivated behavior
Carl Lupica, USA
Novel mechanisms of cocaine-induced endocannabinoid release in brain reward pathways

Room B

16:00

Coffee break

16:30 - 17:50 Plenary Room

Zardi Gori Foundation Symposium

What the young researchers of the Foundation tell us about drug abuse

16:30 - 17:50 Plenary Room

17:50 Plenary room

Conclusion and Awards cerimony